Initial Screening of Convalescent Donors
Recently, social media has been filled with requests for convalescent plasma donors. Although it is still being proven in clinical trials, the use of convalescent donors can be an option for adjuvant therapy or additional therapy for Covid-19 patients.
Various requirements must be observed. Those, among others, were 18-60 years old, had no comorbidities or comorbidities, and prioritized being male. If she is a woman, she has never been pregnant and is not menstruating. "In women who have been pregnant, the HLA (human leukocyte antigen) antibody content will usually increase. It is feared that the HLA content can trigger rejection from the donor recipient's body. Meanwhile, women who menstruate because their metabolic system is not optimal,” said the Primaya Hospital Clinical Pathology Specialist. Physical examinations also need to be carried out on donors. If these conditions are met, further examination is carried out to see the antibody levels in the body. The optimal antibody titer is more than 1:320 and the neutralizing antibody titer is more than 1:80. Convalescent plasma therapy has also been included in the revision of the Covid-19 treatment protocol compiled by five professional organizations, namely the Indonesian Lung Doctors Association, the Indonesian Cardiovascular Specialist Doctors Association, the Indonesian Association of Internal Medicine Specialists, the Indonesian Association of Anesthesiologists and Intensive Therapists, and the Indonesian Association of Internal Medicine. Indonesian Pediatrician. However, clinical trials are currently underway for administration to Covid-19 patients with moderate or at risk of severe symptoms.
|•SOURCE•| Articles :KOMPAS | Image :KEMENPAREKAF |
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